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The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring
The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strateg...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591039/ https://www.ncbi.nlm.nih.gov/pubmed/37716353 http://dx.doi.org/10.1016/j.xcrm.2023.101198 |
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| author | Batool, Syeda Maheen Yekula, Anudeep Khanna, Prerna Hsia, Tiffaney Gamblin, Austin S. Ekanayake, Emil Escobedo, Ana K. You, Dong Gil Castro, Cesar M. Im, Hyungsoon Kilic, Tugba Garlin, Michelle Andrea Skog, Johan Dinulescu, Daniela M. Dudley, Jonathan Agrawal, Nishant Cheng, Jordan Abtin, Fereidoun Aberle, Denise R. Chia, David Elashoff, David Grognan, Tristan Krysan, Kostyantyn Oh, Scott S. Strom, Charles Tu, Michael Wei, Fang Xian, Rena R. Skates, Steven J. Zhang, David Y. Trinh, Thi Watson, Mark Aft, Rebecca Rawal, Siddarth Agarwal, Ashutosh Kesmodel, Susan B. Yang, Changhuei Shen, Cheng Hochberg, Fred H. Wong, David T.W. Patel, Abhijit A. Papadopoulos, Nickolas Bettegowda, Chetan Cote, Richard J. Srivastava, Sudhir Lee, Hakho Carter, Bob S. Balaj, Leonora |
| author_facet | Batool, Syeda Maheen Yekula, Anudeep Khanna, Prerna Hsia, Tiffaney Gamblin, Austin S. Ekanayake, Emil Escobedo, Ana K. You, Dong Gil Castro, Cesar M. Im, Hyungsoon Kilic, Tugba Garlin, Michelle Andrea Skog, Johan Dinulescu, Daniela M. Dudley, Jonathan Agrawal, Nishant Cheng, Jordan Abtin, Fereidoun Aberle, Denise R. Chia, David Elashoff, David Grognan, Tristan Krysan, Kostyantyn Oh, Scott S. Strom, Charles Tu, Michael Wei, Fang Xian, Rena R. Skates, Steven J. Zhang, David Y. Trinh, Thi Watson, Mark Aft, Rebecca Rawal, Siddarth Agarwal, Ashutosh Kesmodel, Susan B. Yang, Changhuei Shen, Cheng Hochberg, Fred H. Wong, David T.W. Patel, Abhijit A. Papadopoulos, Nickolas Bettegowda, Chetan Cote, Richard J. Srivastava, Sudhir Lee, Hakho Carter, Bob S. Balaj, Leonora |
| author_sort | Batool, Syeda Maheen |
| collection | PubMed |
| description | The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays. |
| format | Online Article Text |
| id | pubmed-10591039 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105910392023-10-24 The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring Batool, Syeda Maheen Yekula, Anudeep Khanna, Prerna Hsia, Tiffaney Gamblin, Austin S. Ekanayake, Emil Escobedo, Ana K. You, Dong Gil Castro, Cesar M. Im, Hyungsoon Kilic, Tugba Garlin, Michelle Andrea Skog, Johan Dinulescu, Daniela M. Dudley, Jonathan Agrawal, Nishant Cheng, Jordan Abtin, Fereidoun Aberle, Denise R. Chia, David Elashoff, David Grognan, Tristan Krysan, Kostyantyn Oh, Scott S. Strom, Charles Tu, Michael Wei, Fang Xian, Rena R. Skates, Steven J. Zhang, David Y. Trinh, Thi Watson, Mark Aft, Rebecca Rawal, Siddarth Agarwal, Ashutosh Kesmodel, Susan B. Yang, Changhuei Shen, Cheng Hochberg, Fred H. Wong, David T.W. Patel, Abhijit A. Papadopoulos, Nickolas Bettegowda, Chetan Cote, Richard J. Srivastava, Sudhir Lee, Hakho Carter, Bob S. Balaj, Leonora Cell Rep Med Review The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays. Elsevier 2023-09-15 /pmc/articles/PMC10591039/ /pubmed/37716353 http://dx.doi.org/10.1016/j.xcrm.2023.101198 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Review Batool, Syeda Maheen Yekula, Anudeep Khanna, Prerna Hsia, Tiffaney Gamblin, Austin S. Ekanayake, Emil Escobedo, Ana K. You, Dong Gil Castro, Cesar M. Im, Hyungsoon Kilic, Tugba Garlin, Michelle Andrea Skog, Johan Dinulescu, Daniela M. Dudley, Jonathan Agrawal, Nishant Cheng, Jordan Abtin, Fereidoun Aberle, Denise R. Chia, David Elashoff, David Grognan, Tristan Krysan, Kostyantyn Oh, Scott S. Strom, Charles Tu, Michael Wei, Fang Xian, Rena R. Skates, Steven J. Zhang, David Y. Trinh, Thi Watson, Mark Aft, Rebecca Rawal, Siddarth Agarwal, Ashutosh Kesmodel, Susan B. Yang, Changhuei Shen, Cheng Hochberg, Fred H. Wong, David T.W. Patel, Abhijit A. Papadopoulos, Nickolas Bettegowda, Chetan Cote, Richard J. Srivastava, Sudhir Lee, Hakho Carter, Bob S. Balaj, Leonora The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring |
| title | The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring |
| title_full | The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring |
| title_fullStr | The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring |
| title_full_unstemmed | The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring |
| title_short | The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring |
| title_sort | liquid biopsy consortium: challenges and opportunities for early cancer detection and monitoring |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591039/ https://www.ncbi.nlm.nih.gov/pubmed/37716353 http://dx.doi.org/10.1016/j.xcrm.2023.101198 |
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