Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

The antiviral DNA cytosine deaminase APOBEC3B has been implicated as a source of mutation in many cancers. However, despite years of work, a causal relationship has yet to be established in vivo. Here, we report a murine model that expresses tumor-like levels of human APOBEC3B. Animals expressing fu...

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Detalles Bibliográficos
Autores principales: Durfee, Cameron, Temiz, Nuri Alpay, Levin-Klein, Rena, Argyris, Prokopios P., Alsøe, Lene, Carracedo, Sergio, Alonso de la Vega, Alicia, Proehl, Joshua, Holzhauer, Anna M., Seeman, Zachary J., Liu, Xingyu, Lin, Yu-Hsiu T., Vogel, Rachel I., Sotillo, Rocio, Nilsen, Hilde, Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591044/
https://www.ncbi.nlm.nih.gov/pubmed/37797615
http://dx.doi.org/10.1016/j.xcrm.2023.101211

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