Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics

Neoadjuvant chemotherapy (NAC) for rectal cancer (RC) shows promising clinical response. The modulation of the tumor microenvironment (TME) by NAC and its association with therapeutic response remain unclear. Here, we use single-cell RNA sequencing and spatial transcriptome sequencing to examine the...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Pengfei, Chen, Huaxian, Wang, Yuhang, Huang, Liang, Huang, Ke, Xiao, Guozhong, Han, Changpeng, Hu, Jiancong, Lin, Dezheng, Wan, Xingyang, Zheng, Yihui, Liu, Yufeng, Li, Guiming, Yang, Haojie, Ye, Shubiao, Luo, Minyi, Fu, Yuanji, Xu, Hao, Wen, Luping, Guo, Zhiwei, Shen, Xunan, Li, Zeyu, Wang, Chunqing, Chen, Xi, Wang, Linying, Sun, Liuyong, Ren, Donglin, Wu, Liang, Wang, Jufang, Liu, Shiping, Lin, Hongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591051/
https://www.ncbi.nlm.nih.gov/pubmed/37852187
http://dx.doi.org/10.1016/j.xcrm.2023.101231

Ejemplares similares

Ejemplares similares