Investigating the Roles of Active Site Residues in Mycobacterium tuberculosis Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents

[Image: see text] Mycobacterium tuberculosis drug resistance is emerging and new drug targets are needed. Tryptophan biosynthesis is necessary for M. tuberculosis replication and virulence. Indole-3-glycerol phosphate synthase (IGPS) catalyzes a step in M. tuberculosis tryptophan biosynthesis and ha...

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Detalles Bibliográficos
Autores principales: Konas, David W., Cho, Sarah, Thomas, Oshane D., Bhatti, Maryum M., Leon Hernandez, Katherine, Moran, Cinthya, Booter, Hedda, Candela, Thomas, Lacap, Joseph, McFadden, Paige, van den Berg, Savannah, Welter, Alyssa M., Peralta, Ashley, Janson, Cheryl A., Catalano, Jaclyn, Goodey, Nina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591298/
https://www.ncbi.nlm.nih.gov/pubmed/37876495
http://dx.doi.org/10.1021/acsbiomedchemau.3c00029

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