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Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction

Background: Resection and reconstruction of malignant bone tumors at the proximal femur in adolescent patients has remained a clinical challenge. Considering the growth and development requirements of adolescents, there is no unified standard for the reconstruction of bone defects at the proximal fe...

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Autores principales: Niu, Xiaoying, Tian, Wen, Liang, Xiaoxiao, Yao, Weitao, Zhang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591312/
https://www.ncbi.nlm.nih.gov/pubmed/37877038
http://dx.doi.org/10.3389/fbioe.2023.1248330
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author Niu, Xiaoying
Tian, Wen
Liang, Xiaoxiao
Yao, Weitao
Zhang, Peng
author_facet Niu, Xiaoying
Tian, Wen
Liang, Xiaoxiao
Yao, Weitao
Zhang, Peng
author_sort Niu, Xiaoying
collection PubMed
description Background: Resection and reconstruction of malignant bone tumors at the proximal femur in adolescent patients has remained a clinical challenge. Considering the growth and development requirements of adolescents, there is no unified standard for the reconstruction of bone defects at the proximal femur. Here, we report a case of 3D-printed titanium alloy customized prosthesis for the construction of proximal femoral bone defects in an adolescent patient with Ewing’s sarcoma of the proximal femur. Case presentation: A 7-year-old female patient presented to a local hospital with left hip pain, and was diagnosed with Ewing’s sarcoma on the proximal left femur. The patient received two courses of neoadjuvant chemotherapy before surgery according to the standard protocol. Considering growth and development problems associated with adolescents, we adopted a customized 3D-printed prosthesis of proximal femur for preservation of the femoral head and part of the femoral neck in the affected limb. Clinical outcomes, recorded after 12 months of follow-up, revealed excellent functional recovery and satisfactory functional scores of the affected limb, with no immediate complications. Conclusion: 3D-printed prosthesis is a feasible method for preserving femoral head and reconstruction of bone defects in adolescents’ proximal femur.
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spelling pubmed-105913122023-10-24 Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction Niu, Xiaoying Tian, Wen Liang, Xiaoxiao Yao, Weitao Zhang, Peng Front Bioeng Biotechnol Bioengineering and Biotechnology Background: Resection and reconstruction of malignant bone tumors at the proximal femur in adolescent patients has remained a clinical challenge. Considering the growth and development requirements of adolescents, there is no unified standard for the reconstruction of bone defects at the proximal femur. Here, we report a case of 3D-printed titanium alloy customized prosthesis for the construction of proximal femoral bone defects in an adolescent patient with Ewing’s sarcoma of the proximal femur. Case presentation: A 7-year-old female patient presented to a local hospital with left hip pain, and was diagnosed with Ewing’s sarcoma on the proximal left femur. The patient received two courses of neoadjuvant chemotherapy before surgery according to the standard protocol. Considering growth and development problems associated with adolescents, we adopted a customized 3D-printed prosthesis of proximal femur for preservation of the femoral head and part of the femoral neck in the affected limb. Clinical outcomes, recorded after 12 months of follow-up, revealed excellent functional recovery and satisfactory functional scores of the affected limb, with no immediate complications. Conclusion: 3D-printed prosthesis is a feasible method for preserving femoral head and reconstruction of bone defects in adolescents’ proximal femur. Frontiers Media S.A. 2023-10-09 /pmc/articles/PMC10591312/ /pubmed/37877038 http://dx.doi.org/10.3389/fbioe.2023.1248330 Text en Copyright © 2023 Niu, Tian, Liang, Yao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Niu, Xiaoying
Tian, Wen
Liang, Xiaoxiao
Yao, Weitao
Zhang, Peng
Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
title Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
title_full Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
title_fullStr Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
title_full_unstemmed Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
title_short Ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
title_sort ewing’s sarcoma of proximal femur: case report of extreme osteotomy with 3d-printed prosthesis for the reconstruction
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591312/
https://www.ncbi.nlm.nih.gov/pubmed/37877038
http://dx.doi.org/10.3389/fbioe.2023.1248330
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