Utilizing AAV-mediated LEAPER 2.0 for programmable RNA editing in non-human primates and nonsense mutation correction in humanized Hurler syndrome mice

BACKGROUND: The endogenous adenosine deaminases acting on RNA (ADAR) have been harnessed to facilitate precise adenosine-to-inosine editing on RNAs. However, the practicability of this approach for therapeutic purposes is still ambiguous due to the variable expression of intrinsic ADAR across variou...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Zongyi, Zhao, Yanxia, Yi, Zexuan, Zhang, Yongjian, Tang, Gangbin, Zhang, Xiaoxue, Tang, Huixian, Zhang, Wei, Zhao, Ying, Xu, Huayuan, Nie, Yuyang, Sun, Xueqing, Xing, Lijun, Dai, Lian, Yuan, Pengfei, Wei, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591355/
https://www.ncbi.nlm.nih.gov/pubmed/37872590
http://dx.doi.org/10.1186/s13059-023-03086-6

Ejemplares similares

Ejemplares similares