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Modulation of Structure and Dynamics of Cardiac Troponin by Phosphorylation and Mutations Revealed by Molecular Dynamics Simulations

[Image: see text] Adrenaline acts on β1 receptors in the heart muscle to enhance contractility, increase the heart rate, and increase the rate of relaxation (lusitropy) via activation of the cyclic AMP-dependent protein kinase, PKA. Phosphorylation of serines 22 and 23 in the N-terminal peptide of c...

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Detalles Bibliográficos
Autores principales:	Yang, Zeyu, Marston, Steven B., Gould, Ian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591477/ https://www.ncbi.nlm.nih.gov/pubmed/37791815 http://dx.doi.org/10.1021/acs.jpcb.3c02337

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