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P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.

INTRODUCTION: Slow wave activity during non-rapid eye movement (NREM) sleep has been linked with memory consolidation in healthy older adults. To date, there has been limited research in mild cognitively impaired populations, particularly looking across the whole brain using high density EEG. We aim...

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Autores principales: Chapman, J, Kao, T, Teh, J, Haroutonian, C, Grunstein, R, Naismith, S, D'Rozario, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591574/
http://dx.doi.org/10.1093/sleepadvances/zpad035.132
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author Chapman, J
Kao, T
Teh, J
Haroutonian, C
Grunstein, R
Naismith, S
D'Rozario, A
author_facet Chapman, J
Kao, T
Teh, J
Haroutonian, C
Grunstein, R
Naismith, S
D'Rozario, A
author_sort Chapman, J
collection PubMed
description INTRODUCTION: Slow wave activity during non-rapid eye movement (NREM) sleep has been linked with memory consolidation in healthy older adults. To date, there has been limited research in mild cognitively impaired populations, particularly looking across the whole brain using high density EEG. We aimed to determine if the dynamics of slow wave activity (delta power) during the first NREM sleep cycle differ between patients with mild cognitive impairment (MCI) and healthy older adults. METHODS: Participants were assessed for MCI by a panel of neuropsychologists and clinicians. They underwent full polysomnography including high-density EEG (256 electrodes). We computed the delta power (0.5-4.5Hz) for each NREM cycle and slope between sleep onset and the peak of delta in the first NREM sleep cycle (rise-rate) which were compared between groups using t-tests. RESULTS: 17 older adults with MCI and 21 older healthy controls were assessed. The mean delta power in the first NREM cycle did not differ between MCI and controls across the whole brain, but the global rise-rate (1/min) of MCI and controls was 0.0015 and 0.0032 respectively (t-value -2.35, p=0.025). DISCUSSION: Global slow wave dynamics in the first NREM period appear to be altered in patients with MCI compared with age-matched controls. The gentler slope of rise-rate to the first delta peak in MCI patients than in healthy controls may indicate the dysfunction of sleep homeostasis in MCI patients. Regional slow wave dynamics, ultra-low frequency delta (0.25-1Hz), and associations with sleep dependent memory consolidation will further be explored.
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spelling pubmed-105915742023-10-24 P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study. Chapman, J Kao, T Teh, J Haroutonian, C Grunstein, R Naismith, S D'Rozario, A Sleep Adv Poster Discussion Presentations INTRODUCTION: Slow wave activity during non-rapid eye movement (NREM) sleep has been linked with memory consolidation in healthy older adults. To date, there has been limited research in mild cognitively impaired populations, particularly looking across the whole brain using high density EEG. We aimed to determine if the dynamics of slow wave activity (delta power) during the first NREM sleep cycle differ between patients with mild cognitive impairment (MCI) and healthy older adults. METHODS: Participants were assessed for MCI by a panel of neuropsychologists and clinicians. They underwent full polysomnography including high-density EEG (256 electrodes). We computed the delta power (0.5-4.5Hz) for each NREM cycle and slope between sleep onset and the peak of delta in the first NREM sleep cycle (rise-rate) which were compared between groups using t-tests. RESULTS: 17 older adults with MCI and 21 older healthy controls were assessed. The mean delta power in the first NREM cycle did not differ between MCI and controls across the whole brain, but the global rise-rate (1/min) of MCI and controls was 0.0015 and 0.0032 respectively (t-value -2.35, p=0.025). DISCUSSION: Global slow wave dynamics in the first NREM period appear to be altered in patients with MCI compared with age-matched controls. The gentler slope of rise-rate to the first delta peak in MCI patients than in healthy controls may indicate the dysfunction of sleep homeostasis in MCI patients. Regional slow wave dynamics, ultra-low frequency delta (0.25-1Hz), and associations with sleep dependent memory consolidation will further be explored. Oxford University Press 2023-10-23 /pmc/articles/PMC10591574/ http://dx.doi.org/10.1093/sleepadvances/zpad035.132 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Discussion Presentations
Chapman, J
Kao, T
Teh, J
Haroutonian, C
Grunstein, R
Naismith, S
D'Rozario, A
P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.
title P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.
title_full P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.
title_fullStr P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.
title_full_unstemmed P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.
title_short P047 Slow Wave Dynamics in Mild Cognitive Impairment compared with Age Matched Controls: A High Density EEG study.
title_sort p047 slow wave dynamics in mild cognitive impairment compared with age matched controls: a high density eeg study.
topic Poster Discussion Presentations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591574/
http://dx.doi.org/10.1093/sleepadvances/zpad035.132
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