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P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia

INTRODUCTION: Bright light therapy (BLT) improves sleep and quality of life (QOL) in adults with cancer and adolescents with mood disorders. Children with acute lymphoblastic leukaemia (ALL) are vulnerable to poor sleep, related to their new cancer diagnosis and impaired sleep-wake cycles from dexam...

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Autores principales: Wijayaratne, P, Williams, K, Walter, L, Horne, R, Nixon, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591640/
http://dx.doi.org/10.1093/sleepadvances/zpad035.093
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author Wijayaratne, P
Williams, K
Walter, L
Horne, R
Nixon, G
author_facet Wijayaratne, P
Williams, K
Walter, L
Horne, R
Nixon, G
author_sort Wijayaratne, P
collection PubMed
description INTRODUCTION: Bright light therapy (BLT) improves sleep and quality of life (QOL) in adults with cancer and adolescents with mood disorders. Children with acute lymphoblastic leukaemia (ALL) are vulnerable to poor sleep, related to their new cancer diagnosis and impaired sleep-wake cycles from dexamethasone treatment. To date no studies have investigated the feasibility and utility of BLT to improve sleep, daytime functioning and QOL in this population. METHODS: The intervention group (N=7) underwent BLT for 30 minutes each morning during dexamethasone treatment. Actigraphy and psychometric questionnaires measured at baseline, at the end of dexamethasone treatment and at six months post treatment, in addition to actigraphy following three dexamethasone treatments, were compared between the intervention and non-intervention groups (N=5). Feasibility measures included study acceptance, retention and limited efficacy testing. RESULTS: The Moods and Feelings questionnaire and both the child and parent reported PedsQL Multidimensional Fatigue Scale had the lowest completion rates both at the end of treatment or at follow up for BLT (57-67%) and in the non-intervention group (50-60%). Negligible differences were observed in sleep outcomes during dexamethasone treatment between the two groups. The largest effect sizes of BLT were seen for total sleep time, sleep efficiency and wake after sleep onset at the end of dexamethasone treatment and at follow up. DISCUSSION: This study demonstrates limited preliminary feasibility of BLT in children with ALL during dexamethasone treatment. A successful future trial should consider modifications to the data collection periods and the type of questionnaires.
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spelling pubmed-105916402023-10-24 P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia Wijayaratne, P Williams, K Walter, L Horne, R Nixon, G Sleep Adv Poster Discussion Presentations INTRODUCTION: Bright light therapy (BLT) improves sleep and quality of life (QOL) in adults with cancer and adolescents with mood disorders. Children with acute lymphoblastic leukaemia (ALL) are vulnerable to poor sleep, related to their new cancer diagnosis and impaired sleep-wake cycles from dexamethasone treatment. To date no studies have investigated the feasibility and utility of BLT to improve sleep, daytime functioning and QOL in this population. METHODS: The intervention group (N=7) underwent BLT for 30 minutes each morning during dexamethasone treatment. Actigraphy and psychometric questionnaires measured at baseline, at the end of dexamethasone treatment and at six months post treatment, in addition to actigraphy following three dexamethasone treatments, were compared between the intervention and non-intervention groups (N=5). Feasibility measures included study acceptance, retention and limited efficacy testing. RESULTS: The Moods and Feelings questionnaire and both the child and parent reported PedsQL Multidimensional Fatigue Scale had the lowest completion rates both at the end of treatment or at follow up for BLT (57-67%) and in the non-intervention group (50-60%). Negligible differences were observed in sleep outcomes during dexamethasone treatment between the two groups. The largest effect sizes of BLT were seen for total sleep time, sleep efficiency and wake after sleep onset at the end of dexamethasone treatment and at follow up. DISCUSSION: This study demonstrates limited preliminary feasibility of BLT in children with ALL during dexamethasone treatment. A successful future trial should consider modifications to the data collection periods and the type of questionnaires. Oxford University Press 2023-10-23 /pmc/articles/PMC10591640/ http://dx.doi.org/10.1093/sleepadvances/zpad035.093 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Poster Discussion Presentations
Wijayaratne, P
Williams, K
Walter, L
Horne, R
Nixon, G
P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
title P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
title_full P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
title_fullStr P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
title_full_unstemmed P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
title_short P008 Pilot and Feasibility of Bright Light Therapy in Improving Sleep and Quality of Life in Children with Acute Lymphoblastic Leukaemia
title_sort p008 pilot and feasibility of bright light therapy in improving sleep and quality of life in children with acute lymphoblastic leukaemia
topic Poster Discussion Presentations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591640/
http://dx.doi.org/10.1093/sleepadvances/zpad035.093
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