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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

Amplified lysosome activity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) orchestrated by oncogenic KRAS that mediates tumor growth and metastasis, though the mechanisms underlying this phenomenon remain unclear. Using comparative proteomics, we found that oncogenic KRAS significantly enr...

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Detalles Bibliográficos
Autores principales:	Gutierrez-Ruiz, Omar L., Johnson, Katherine M., Krueger, Eugene W., Nooren, Roseanne E., Cruz-Reyes, Nicole, Heppelmann, Carrie Jo, Hogenson, Tara L., Fernandez-Zapico, Martin E., McNiven, Mark A., Razidlo, Gina L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591794/ https://www.ncbi.nlm.nih.gov/pubmed/37651233 http://dx.doi.org/10.1016/j.celrep.2023.113042

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