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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
Cells can irreversibly exit the cell cycle and become senescent to safeguard against uncontrolled proliferation. While the p53-p21 and p16-Rb pathways are thought to mediate senescence, they also mediate reversible cell cycle arrest (quiescence), raising the question of whether senescence is actuall...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591853/ https://www.ncbi.nlm.nih.gov/pubmed/37656618 http://dx.doi.org/10.1016/j.celrep.2023.113079 |