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Pathological Bergmann glia alterations and disrupted calcium dynamics in ataxic Canavan disease mice

Canavan disease (CD) is a recessively inherited pediatric leukodystrophy resulting from inactivating mutations to the oligodendroglial enzyme aspartoacylase (ASPA). ASPA is responsible for hydrolyzing the amino acid derivative N-acetyl-L-aspartate (NAA), and without it, brain NAA concentrations incr...

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Detalles Bibliográficos
Autores principales:	Hull, Vanessa L., Wang, Yan, Burns, Travis, Sternbach, Sarah, Gong, Shuaishuai, McDonough, Jennifer, Guo, Fuzheng, Borodinsky, Laura N., Pleasure, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591969/ https://www.ncbi.nlm.nih.gov/pubmed/37610133 http://dx.doi.org/10.1002/glia.24454

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