Cargando…
Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism
[Image: see text] The structure and mechanism of the bacterial enzyme β-lactamase have been well-studied due to its clinical role in antibiotic resistance. β-Lactamase is known to hydrolyze the β-lactam ring of the cephalosporin scaffold, allowing a spontaneous self-immolation to occur. Previously,...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592181/ https://www.ncbi.nlm.nih.gov/pubmed/37326511 http://dx.doi.org/10.1021/acschembio.3c00027 |