Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression

Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread production of truncated proteins is unclear. A human genetic disease, facioscapulohume...

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Detalles Bibliográficos
Autores principales: Campbell, Amy E., Dyle, Michael C., Albanese, Roberto, Matheny, Tyler, Sudheendran, Kavitha, Cortázar, Michael A., Forman, Thomas, Fu, Rui, Gillen, Austin E., Caruthers, Marvin H., Floor, Stephen N., Calviello, Lorenzo, Jagannathan, Sujatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592454/
https://www.ncbi.nlm.nih.gov/pubmed/37314931
http://dx.doi.org/10.1016/j.celrep.2023.112642

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