Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

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Type 2 diabetes is characterized by insulin hypersecretion followed by reduced glucose-stimulated insulin secretion (GSIS). Here we show that acute stimulation of pancreatic islets with the insulin secretagogue dextrorphan (DXO) or glibenclamide enhances GSIS, whereas chronic treatment with high con...

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Detalles Bibliográficos
Autores principales: Pelligra, Angela, Mrugala, Jessica, Griess, Kerstin, Kirschner, Philip, Nortmann, Oliver, Bartosinska, Barbara, Köster, Andrea, Krupenko, Natalia I., Gebel, Dominik, Westhoff, Philipp, Steckel, Bodo, Eberhard, Daniel, Herebian, Diran, Belgardt, Bengt-Frederik, Schrader, Jürgen, Weber, Andreas P.M., Krupenko, Sergey A., Lammert, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592470/
https://www.ncbi.nlm.nih.gov/pubmed/37294632
http://dx.doi.org/10.1016/j.celrep.2023.112615
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