5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

Disseminated cancer cells (DCCs) in secondary organs can remain dormant for years to decades before re-activating into overt metastasis. Microenvironmental signals leading to cancer cell chromatin remodeling and transcriptional reprogramming appear to control onset and escape from dormancy. Here, we...

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Detalles Bibliográficos
Autores principales: Singh, Deepak K., Carcamo, Saul, Farias, Eduardo F., Hasson, Dan, Zheng, Wei, Sun, Dan, Huang, Xin, Cheung, Julie, Nobre, Ana Rita, Kale, Nupura, Sosa, Maria Soledad, Bernstein, Emily, Aguirre-Ghiso, Julio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592471/
https://www.ncbi.nlm.nih.gov/pubmed/37267946
http://dx.doi.org/10.1016/j.celrep.2023.112560

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