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Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes

Branched-chain amino acid (BCAA) metabolism is linked to glucose homeostasis, but the underlying signaling mechanisms are unclear. We find that gluconeogenesis is reduced in mice deficient of Ppm1k, a positive regulator of BCAA catabolism, which protects against obesity-induced glucose intolerance....

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Detalles Bibliográficos
Autores principales:	Nishi, Kiyoto, Yoshii, Akira, Abell, Lauren, Zhou, Bo, Frausto, Ricardo, Ritterhoff, Julia, McMillen, Timothy S., Sweet, Ian, Wang, Yibin, Gao, Chen, Tian, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592489/ https://www.ncbi.nlm.nih.gov/pubmed/37310861 http://dx.doi.org/10.1016/j.celrep.2023.112641

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