G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat oxidative stress and support reductive biosynthesis. One major NAPDH production route is the oxidative pentose phosphate pathway (committed step: glucose-6-phosphate dehydrogenase, G6PD). Alternatives exist and can...

Descripción completa

Detalles Bibliográficos
Autores principales: Lan, Taijin, Arastu, Sara, Wang, Samuel, Lam, Jarrick, Wang, Wenping, Bhatt, Vrushank, Lopes, Eduardo Cararo, Hu, Zhixian, Sun, Michael, Luo, Xuefei, Ghergurovich, Jonathan M., Li, Changlong, Su, Xiaoyang, Rabinowitz, Joshua D., White, Eileen, Guo, Jessie Yanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592603/
https://www.ncbi.nlm.nih.gov/pubmed/37873106
http://dx.doi.org/10.1101/2023.10.06.561131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592603/
https://www.ncbi.nlm.nih.gov/pubmed/37873106
http://dx.doi.org/10.1101/2023.10.06.561131

Ejemplares similares