Triple-action inhibitory mechanism of allosteric TYK2-specific inhibitors

Deucravacitinib, 6-(cyclopropanecarbonylamido)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide, is a highly selective inhibitor of protein tyrosine kinase 2 (TYK2) that targets the Janus kinase (JAK)-signal transducer and activator of transcription...

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Detalles Bibliográficos
Autores principales: Wang, Jimin, Batista, Victor S., Bunick, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592677/
https://www.ncbi.nlm.nih.gov/pubmed/37873392
http://dx.doi.org/10.1101/2023.10.09.561507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592677/
https://www.ncbi.nlm.nih.gov/pubmed/37873392
http://dx.doi.org/10.1101/2023.10.09.561507

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