Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues

Small molecules that can induce protein degradation by inducing proximity between a desired target and an E3 ligase have the potential to greatly expand the number of proteins that can be manipulated pharmacologically. Current strategies for targeted protein degradation are mostly limited in their t...

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Detalles Bibliográficos
Autores principales: Hassan, Muhammad Murtaza, Li, Yen-Der, Ma, Michelle W., Teng, Mingxing, Byun, Woong Sub, Puvar, Kedar, Lumpkin, Ryan, Sandoval, Brittany, Rutter, Justine C., Jin, Cyrus Y., Wang, Michelle Y., Xu, Shawn, Schmoker, Anna M., Cheong, Hakyung, Groendyke, Brian J., Qi, Jun, Fischer, Eric S., Ebert, Benjamin L., Gray, Nathanael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592706/
https://www.ncbi.nlm.nih.gov/pubmed/37873358
http://dx.doi.org/10.1101/2023.10.07.561308

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