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Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia

Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment refractory. We analyzed previously published AML relapse cohorts and found that 40% of relapses occur without changes in driver mutations, suggesting that non-genetic mechanisms drive relapse in a large proportion of ca...

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Detalles Bibliográficos
Autores principales:	Nuno, Kevin A., Azizi, Armon, Köhnke, Thomas, Lareau, Caleb A., Ediwirickrema, Asiri, Ryan Corces, M., Satpathy, Ansuman T., Majeti, Ravindra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592718/ https://www.ncbi.nlm.nih.gov/pubmed/37873452 http://dx.doi.org/10.1101/2023.10.10.561642

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