Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases

Most cellular ubiquitin signaling is initiated by UBA1, which activates and transfers ubiquitin to tens of E2 enzymes. Clonally acquired UBA1 missense mutations cause an inflammatory-hematologic overlap disease called VEXAS (vacuoles, E1, X-linked, autoinflammatory, somatic) syndrome. Despite extens...

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Detalles Bibliográficos
Autores principales: Collins, Jason C., Magaziner, Samuel J., English, Maya, Hassan, Bakar, Chen, Xiang, Balanda, Nicholas, Anderson, Meghan, Lam, Athena, Fernandez-Pol, Sebastian, Kwong, Bernice, Greenberg, Peter L., Terrier, Benjamin, Likhite, Mary E., Kosmider, Olivier, Wang, Yan, Samara, Nadine L., Walters, Kylie J., Beck, David B., Werner, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592724/
https://www.ncbi.nlm.nih.gov/pubmed/37873213
http://dx.doi.org/10.1101/2023.10.10.561769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592724/
https://www.ncbi.nlm.nih.gov/pubmed/37873213
http://dx.doi.org/10.1101/2023.10.10.561769

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