Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCF(βTrCP). However, the magni...

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Detalles Bibliográficos
Autores principales: Mouery, Ryan D, Hsu, Carolyn, Bonacci, Thomas, Bolhuis, Derek L, Wang, Xianxi, Mills, Christine A, Toomer, E Drew, Canterbury, Owen G, Robertson, Kevin C, Branigan, Timothy B, Brown, Nicholas G, Herring, Laura E, Emanuele, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592729/
https://www.ncbi.nlm.nih.gov/pubmed/37873169
http://dx.doi.org/10.1101/2023.10.11.561963

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