State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia (CML)

Chronic myeloid leukemia (CML) is initiated and initially maintained solely by the fusion gene BCR-ABL, encoding a multifaceted chimeric kinase targeted in the clinic with tyrosine kinase inhibitors (TKIs) TKIs are effective in inducing long-term remission, but are also frequently not curative. Thus...

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Detalles Bibliográficos
Autores principales: Frankhouser, David E., Rockne, Russell C., Uechi, Lisa, Zhao, Dandan, Branciamore, Sergio, O’Meally, Denis, Izarriy, Jihyun, Ghoda, Lucy, Ali, Haris, Trent, Jeffery M., Forman, Stephen, Fu, Yu-Hsuan, Kuo, Ya-Huei, Zhang, Bin, Marcucci, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592732/
https://www.ncbi.nlm.nih.gov/pubmed/37873185
http://dx.doi.org/10.1101/2023.10.11.561908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592732/
https://www.ncbi.nlm.nih.gov/pubmed/37873185
http://dx.doi.org/10.1101/2023.10.11.561908

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