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Harnessing Generative AI to Decode Enzyme Catalysis and Evolution for Enhanced Engineering

Enzymes, as paramount protein catalysts, occupy a central role in fostering remarkable progress across numerous fields. However, the intricacy of sequence-function relationships continues to obscure our grasp of enzyme behaviors and curtails our capabilities in rational enzyme engineering. Generativ...

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Detalles Bibliográficos
Autores principales: Xie, Wen Jun, Warshel, Arieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592750/
https://www.ncbi.nlm.nih.gov/pubmed/37873334
http://dx.doi.org/10.1101/2023.10.10.561808