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STING induces LUBAC-mediated synthesis of linear ubiquitin chains to stimulate innate immune signaling

STING activation by cyclic dinucleotides in mammals induces interferon- and NFκB -related gene expression, and the lipidation of LC3B at Golgi membranes. While mechanisms of the interferon response are well understood, the mechanisms of NFκB activation mediated by STING remain unclear. We report tha...

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Detalles Bibliográficos
Autores principales:	Fischer, Tara D., Bunker, Eric N., Zhu, Peng-Peng, Le Guerroué, François, Dominguez-Martin, Eunice, Scavone, Francesco, Cohen, Robert, Yao, Tingting, Wang, Yan, Werner, Achim, Youle, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592814/ https://www.ncbi.nlm.nih.gov/pubmed/37873486 http://dx.doi.org/10.1101/2023.10.14.562349

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