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Initiation of a ZAKα-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L

RNase L is a regulated endoribonuclease in higher vertebrates that functions in antiviral innate immunity. Interferons induce OAS enzymes that sense double-stranded RNA of viral origin leading to synthesis of 2’,5’-oligoadenylate (2–5A) activators of RNase L. However, it is unknown precisely how RNa...

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Detalles Bibliográficos
Autores principales:	Xi, Jiajia, Snieckute, Goda, Asthana, Abhishek, Gaughan, Christina, Bekker-Jensen, Simon, Silverman, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592832/ https://www.ncbi.nlm.nih.gov/pubmed/37873202 http://dx.doi.org/10.1101/2023.10.12.562082

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