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Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism

Physical activity is a modifiable lifestyle factor that is associated with a decreased risk for the development of breast cancer. While the exact mechanisms for the reduction in cancer risk due to physical activity are largely unknown, it is postulated that the biological reduction in cancer risk is...

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Autores principales: Khair, Lyne, Hayes, Katherine, Tutto, Amanda, Samant, Amruta, Ferreira, Lindsay, Nguyen, Tammy T., Brehm, Michael, Messina, Louis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592839/
https://www.ncbi.nlm.nih.gov/pubmed/37873380
http://dx.doi.org/10.1101/2023.09.30.560299
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author Khair, Lyne
Hayes, Katherine
Tutto, Amanda
Samant, Amruta
Ferreira, Lindsay
Nguyen, Tammy T.
Brehm, Michael
Messina, Louis M.
author_facet Khair, Lyne
Hayes, Katherine
Tutto, Amanda
Samant, Amruta
Ferreira, Lindsay
Nguyen, Tammy T.
Brehm, Michael
Messina, Louis M.
author_sort Khair, Lyne
collection PubMed
description Physical activity is a modifiable lifestyle factor that is associated with a decreased risk for the development of breast cancer. While the exact mechanisms for the reduction in cancer risk due to physical activity are largely unknown, it is postulated that the biological reduction in cancer risk is driven by improvements in inflammation and immune function with exercise. Hematopoietic stem cells (HSCs) are the progenitor for all of the cells of the immune system and are involved in cancer immunosurveillance through differentiation into cytotoxic cell population. In this study, we investigate the role of physical activity (PA) in a spontaneously occurring model of breast cancer over time, with a focus on tumor incidence, circulating and tumor-infiltrating immune cells as well gene expression profiles of tumors and hematopoietic stem cells. Furthermore, we show that, in addition to a direct effect of PA on the immune cells of tumor-bearing mice, PA reduces the oxidative stress in HSCs of wildtype and tumor-bearing mice, and by doing so, alters the differentiation of the HSCs towards T cells in order to enhance cancer immunosurveillance.
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spelling pubmed-105928392023-10-24 Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism Khair, Lyne Hayes, Katherine Tutto, Amanda Samant, Amruta Ferreira, Lindsay Nguyen, Tammy T. Brehm, Michael Messina, Louis M. bioRxiv Article Physical activity is a modifiable lifestyle factor that is associated with a decreased risk for the development of breast cancer. While the exact mechanisms for the reduction in cancer risk due to physical activity are largely unknown, it is postulated that the biological reduction in cancer risk is driven by improvements in inflammation and immune function with exercise. Hematopoietic stem cells (HSCs) are the progenitor for all of the cells of the immune system and are involved in cancer immunosurveillance through differentiation into cytotoxic cell population. In this study, we investigate the role of physical activity (PA) in a spontaneously occurring model of breast cancer over time, with a focus on tumor incidence, circulating and tumor-infiltrating immune cells as well gene expression profiles of tumors and hematopoietic stem cells. Furthermore, we show that, in addition to a direct effect of PA on the immune cells of tumor-bearing mice, PA reduces the oxidative stress in HSCs of wildtype and tumor-bearing mice, and by doing so, alters the differentiation of the HSCs towards T cells in order to enhance cancer immunosurveillance. Cold Spring Harbor Laboratory 2023-10-02 /pmc/articles/PMC10592839/ /pubmed/37873380 http://dx.doi.org/10.1101/2023.09.30.560299 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Khair, Lyne
Hayes, Katherine
Tutto, Amanda
Samant, Amruta
Ferreira, Lindsay
Nguyen, Tammy T.
Brehm, Michael
Messina, Louis M.
Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
title Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
title_full Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
title_fullStr Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
title_full_unstemmed Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
title_short Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
title_sort physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592839/
https://www.ncbi.nlm.nih.gov/pubmed/37873380
http://dx.doi.org/10.1101/2023.09.30.560299
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