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Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations

Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special ch...

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Detalles Bibliográficos
Autores principales: Hou, Kangcheng, Gogarten, Stephanie, Kim, Joohyun, Hua, Xing, Dias, Julie-Alexia, Sun, Quan, Wang, Ying, Tan, Taotao, Atkinson, Elizabeth G., Martin, Alicia, Shortt, Jonathan, Hirbo, Jibril, Li, Yun, Pasaniuc, Bogdan, Zhang, Haoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592849/
https://www.ncbi.nlm.nih.gov/pubmed/37873338
http://dx.doi.org/10.1101/2023.09.30.560263
Descripción
Sumario:Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations.