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Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations

Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special ch...

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Autores principales: Hou, Kangcheng, Gogarten, Stephanie, Kim, Joohyun, Hua, Xing, Dias, Julie-Alexia, Sun, Quan, Wang, Ying, Tan, Taotao, Atkinson, Elizabeth G., Martin, Alicia, Shortt, Jonathan, Hirbo, Jibril, Li, Yun, Pasaniuc, Bogdan, Zhang, Haoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592849/
https://www.ncbi.nlm.nih.gov/pubmed/37873338
http://dx.doi.org/10.1101/2023.09.30.560263
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author Hou, Kangcheng
Gogarten, Stephanie
Kim, Joohyun
Hua, Xing
Dias, Julie-Alexia
Sun, Quan
Wang, Ying
Tan, Taotao
Atkinson, Elizabeth G.
Martin, Alicia
Shortt, Jonathan
Hirbo, Jibril
Li, Yun
Pasaniuc, Bogdan
Zhang, Haoyu
author_facet Hou, Kangcheng
Gogarten, Stephanie
Kim, Joohyun
Hua, Xing
Dias, Julie-Alexia
Sun, Quan
Wang, Ying
Tan, Taotao
Atkinson, Elizabeth G.
Martin, Alicia
Shortt, Jonathan
Hirbo, Jibril
Li, Yun
Pasaniuc, Bogdan
Zhang, Haoyu
author_sort Hou, Kangcheng
collection PubMed
description Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations.
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spelling pubmed-105928492023-10-24 Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations Hou, Kangcheng Gogarten, Stephanie Kim, Joohyun Hua, Xing Dias, Julie-Alexia Sun, Quan Wang, Ying Tan, Taotao Atkinson, Elizabeth G. Martin, Alicia Shortt, Jonathan Hirbo, Jibril Li, Yun Pasaniuc, Bogdan Zhang, Haoyu bioRxiv Article Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations. Cold Spring Harbor Laboratory 2023-10-02 /pmc/articles/PMC10592849/ /pubmed/37873338 http://dx.doi.org/10.1101/2023.09.30.560263 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Hou, Kangcheng
Gogarten, Stephanie
Kim, Joohyun
Hua, Xing
Dias, Julie-Alexia
Sun, Quan
Wang, Ying
Tan, Taotao
Atkinson, Elizabeth G.
Martin, Alicia
Shortt, Jonathan
Hirbo, Jibril
Li, Yun
Pasaniuc, Bogdan
Zhang, Haoyu
Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
title Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
title_full Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
title_fullStr Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
title_full_unstemmed Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
title_short Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
title_sort admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592849/
https://www.ncbi.nlm.nih.gov/pubmed/37873338
http://dx.doi.org/10.1101/2023.09.30.560263
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