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Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations
Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special ch...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592849/ https://www.ncbi.nlm.nih.gov/pubmed/37873338 http://dx.doi.org/10.1101/2023.09.30.560263 |
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author | Hou, Kangcheng Gogarten, Stephanie Kim, Joohyun Hua, Xing Dias, Julie-Alexia Sun, Quan Wang, Ying Tan, Taotao Atkinson, Elizabeth G. Martin, Alicia Shortt, Jonathan Hirbo, Jibril Li, Yun Pasaniuc, Bogdan Zhang, Haoyu |
author_facet | Hou, Kangcheng Gogarten, Stephanie Kim, Joohyun Hua, Xing Dias, Julie-Alexia Sun, Quan Wang, Ying Tan, Taotao Atkinson, Elizabeth G. Martin, Alicia Shortt, Jonathan Hirbo, Jibril Li, Yun Pasaniuc, Bogdan Zhang, Haoyu |
author_sort | Hou, Kangcheng |
collection | PubMed |
description | Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations. |
format | Online Article Text |
id | pubmed-10592849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-105928492023-10-24 Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations Hou, Kangcheng Gogarten, Stephanie Kim, Joohyun Hua, Xing Dias, Julie-Alexia Sun, Quan Wang, Ying Tan, Taotao Atkinson, Elizabeth G. Martin, Alicia Shortt, Jonathan Hirbo, Jibril Li, Yun Pasaniuc, Bogdan Zhang, Haoyu bioRxiv Article Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations. Cold Spring Harbor Laboratory 2023-10-02 /pmc/articles/PMC10592849/ /pubmed/37873338 http://dx.doi.org/10.1101/2023.09.30.560263 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Hou, Kangcheng Gogarten, Stephanie Kim, Joohyun Hua, Xing Dias, Julie-Alexia Sun, Quan Wang, Ying Tan, Taotao Atkinson, Elizabeth G. Martin, Alicia Shortt, Jonathan Hirbo, Jibril Li, Yun Pasaniuc, Bogdan Zhang, Haoyu Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations |
title | Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations |
title_full | Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations |
title_fullStr | Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations |
title_full_unstemmed | Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations |
title_short | Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations |
title_sort | admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592849/ https://www.ncbi.nlm.nih.gov/pubmed/37873338 http://dx.doi.org/10.1101/2023.09.30.560263 |
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