Cargando…
Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer
Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. It manifests along multiple phenotypic axes and decoding the interconnections among these different axes is crucial to understand its molecular origins and to develop...
Autores principales: | Sahoo, Sarthak, Ramu, Soundharya, Nair, Madhumathy G, Pillai, Maalavika, San Juan, Beatriz P, Milioli, Heloisa Zaccaron, Mandal, Susmita, Naidu, Chandrakala M, Mavatkar, Apoorva D, Subramaniam, Harini, Neogi, Arpita G, Chaffer, Christine L, Prabhu, Jyothi S, Somarelli, Jason A, Jolly, Mohit Kumar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592858/ https://www.ncbi.nlm.nih.gov/pubmed/37873432 http://dx.doi.org/10.1101/2023.09.30.558960 |
Ejemplares similares
-
An androgen receptor regulated gene score is associated with epithelial to mesenchymal transition features in triple negative breast cancers
por: Rajarajan, Savitha, et al.
Publicado: (2023) -
The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition
por: Subbalakshmi, Ayalur Raghu, et al.
Publicado: (2023) -
Estimation of ALU Repetitive Elements in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer
por: Nair, Madhumathy G., et al.
Publicado: (2023) -
Systems-level network modeling deciphers the master regulators of phenotypic plasticity and heterogeneity in melanoma
por: Pillai, Maalavika, et al.
Publicado: (2021) -
A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticity
por: Shyam, Sai, et al.
Publicado: (2023)