ARF6-dependent endocytic trafficking of the Interferon-γ receptor drives adaptive immune resistance in cancer

Adaptive immune resistance (AIR) is a protective process used by cancer to escape elimination by CD8(+) T cells. Inhibition of immune checkpoints PD-1 and CTLA-4 specifically target Interferon-gamma (IFNγ)-driven AIR. AIR begins at the plasma membrane where tumor cell-intrinsic cytokine signaling is...

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Detalles Bibliográficos
Autores principales: Wee, Yinshen, Wang, Junhua, Wilson, Emily C., Rich, Coulson P., Rogers, Aaron, Tong, Zongzhong, DeGroot, Evelyn, Gopal, Y.N. Vashisht, Davies, Michael A., Ekiz, H. Atakan, Tay, Joshua K.H., Stubben, Chris, Boucher, Kenneth M., Oviedo, Juan M., Fairfax, Keke C., Williams, Matthew A., Holmen, Sheri L., Wolff, Roger K., Grossmann, Allie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592860/
https://www.ncbi.nlm.nih.gov/pubmed/37873189
http://dx.doi.org/10.1101/2023.09.29.560199

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