Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

We previously reported that acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL2, creating a therapeutic opportunity to target LSCs using the BCL2 inhibitor drug venetoclax. While veneto...

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Detalles Bibliográficos
Autores principales: Sheth, Anagha Inguva, Engel, Krysta, Tolison, Hunter, Althoff, Mark J, Amaya, Maria L., Krug, Anna, Young, Tracy, Pei, Shanshan, Patel, Sweta B., Minhajuddin, Mohammad, Winters, Amanda, Miller, Regan, Shelton, Ian, St-Germain, Jonathan, Ling, Tianyi, Jones, Courtney, Raught, Brian, Gillen, Austin, Ransom, Monica, Staggs, Sarah, Smith, Clayton A., Pollyea, Daniel A., Stevens, Brett M., Jordan, Craig T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592899/
https://www.ncbi.nlm.nih.gov/pubmed/37873284
http://dx.doi.org/10.1101/2023.10.02.560330

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