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Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation
Bioelectronic fibers hold promise for both research and clinical applications due to their compactness, ease of implantation, and ability to incorporate various functionalities such as sensing and stimulation. However, existing devices suffer from bulkiness, rigidity, limited functionality, and low...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592902/ https://www.ncbi.nlm.nih.gov/pubmed/37873341 http://dx.doi.org/10.1101/2023.10.02.560482 |
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author | Khatib, Muhammad Zhao, Eric Tianjiao Wei, Shiyuan Abramson, Alex Bishop, Estelle Spear Chen, Chih-Hsin Thomas, Anne-Laure Xu, Chengyi Park, Jaeho Lee, Yeongjun Hamnett, Ryan Yu, Weilai Root, Samuel E. Yuan, Lei Chakhtoura, Dorine Kim, Kyun Kyu Zhong, Donglai Nishio, Yuya Zhao, Chuanzhen Wu, Can Jiang, Yuanwen Zhang, Anqi Li, Jinxing Wang, Weichen Salimi-Jazi, Fereshteh Rafeeqi, Talha A. Hemed, Nofar Mintz Tok, Jeffrey B.-H. Chen, Xiaoke Kaltschmidt, Julia A. Dunn, James C.Y. Bao, Zhenan |
author_facet | Khatib, Muhammad Zhao, Eric Tianjiao Wei, Shiyuan Abramson, Alex Bishop, Estelle Spear Chen, Chih-Hsin Thomas, Anne-Laure Xu, Chengyi Park, Jaeho Lee, Yeongjun Hamnett, Ryan Yu, Weilai Root, Samuel E. Yuan, Lei Chakhtoura, Dorine Kim, Kyun Kyu Zhong, Donglai Nishio, Yuya Zhao, Chuanzhen Wu, Can Jiang, Yuanwen Zhang, Anqi Li, Jinxing Wang, Weichen Salimi-Jazi, Fereshteh Rafeeqi, Talha A. Hemed, Nofar Mintz Tok, Jeffrey B.-H. Chen, Xiaoke Kaltschmidt, Julia A. Dunn, James C.Y. Bao, Zhenan |
author_sort | Khatib, Muhammad |
collection | PubMed |
description | Bioelectronic fibers hold promise for both research and clinical applications due to their compactness, ease of implantation, and ability to incorporate various functionalities such as sensing and stimulation. However, existing devices suffer from bulkiness, rigidity, limited functionality, and low density of active components. These limitations stem from the difficulty to incorporate many components on one-dimensional (1D) fiber devices due to the incompatibility of conventional microfabrication methods (e.g., photolithography) with curved, thin and long fiber structures. Herein, we introduce a fabrication approach, ‶spiral transformation″, to convert two-dimensional (2D) films containing microfabricated devices into 1D soft fibers. This approach allows for the creation of high density multimodal soft bioelectronic fibers, termed Spiral NeuroString (S-NeuroString), while enabling precise control over the longitudinal, angular, and radial positioning and distribution of the functional components. We show the utility of S-NeuroString for motility mapping, serotonin sensing, and tissue stimulation within the dynamic and soft gastrointestinal (GI) system, as well as for single-unit recordings in the brain. The described bioelectronic fibers hold great promises for next-generation multifunctional implantable electronics. |
format | Online Article Text |
id | pubmed-10592902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-105929022023-10-24 Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation Khatib, Muhammad Zhao, Eric Tianjiao Wei, Shiyuan Abramson, Alex Bishop, Estelle Spear Chen, Chih-Hsin Thomas, Anne-Laure Xu, Chengyi Park, Jaeho Lee, Yeongjun Hamnett, Ryan Yu, Weilai Root, Samuel E. Yuan, Lei Chakhtoura, Dorine Kim, Kyun Kyu Zhong, Donglai Nishio, Yuya Zhao, Chuanzhen Wu, Can Jiang, Yuanwen Zhang, Anqi Li, Jinxing Wang, Weichen Salimi-Jazi, Fereshteh Rafeeqi, Talha A. Hemed, Nofar Mintz Tok, Jeffrey B.-H. Chen, Xiaoke Kaltschmidt, Julia A. Dunn, James C.Y. Bao, Zhenan bioRxiv Article Bioelectronic fibers hold promise for both research and clinical applications due to their compactness, ease of implantation, and ability to incorporate various functionalities such as sensing and stimulation. However, existing devices suffer from bulkiness, rigidity, limited functionality, and low density of active components. These limitations stem from the difficulty to incorporate many components on one-dimensional (1D) fiber devices due to the incompatibility of conventional microfabrication methods (e.g., photolithography) with curved, thin and long fiber structures. Herein, we introduce a fabrication approach, ‶spiral transformation″, to convert two-dimensional (2D) films containing microfabricated devices into 1D soft fibers. This approach allows for the creation of high density multimodal soft bioelectronic fibers, termed Spiral NeuroString (S-NeuroString), while enabling precise control over the longitudinal, angular, and radial positioning and distribution of the functional components. We show the utility of S-NeuroString for motility mapping, serotonin sensing, and tissue stimulation within the dynamic and soft gastrointestinal (GI) system, as well as for single-unit recordings in the brain. The described bioelectronic fibers hold great promises for next-generation multifunctional implantable electronics. Cold Spring Harbor Laboratory 2023-10-03 /pmc/articles/PMC10592902/ /pubmed/37873341 http://dx.doi.org/10.1101/2023.10.02.560482 Text en https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Khatib, Muhammad Zhao, Eric Tianjiao Wei, Shiyuan Abramson, Alex Bishop, Estelle Spear Chen, Chih-Hsin Thomas, Anne-Laure Xu, Chengyi Park, Jaeho Lee, Yeongjun Hamnett, Ryan Yu, Weilai Root, Samuel E. Yuan, Lei Chakhtoura, Dorine Kim, Kyun Kyu Zhong, Donglai Nishio, Yuya Zhao, Chuanzhen Wu, Can Jiang, Yuanwen Zhang, Anqi Li, Jinxing Wang, Weichen Salimi-Jazi, Fereshteh Rafeeqi, Talha A. Hemed, Nofar Mintz Tok, Jeffrey B.-H. Chen, Xiaoke Kaltschmidt, Julia A. Dunn, James C.Y. Bao, Zhenan Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation |
title | Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation |
title_full | Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation |
title_fullStr | Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation |
title_full_unstemmed | Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation |
title_short | Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation |
title_sort | spiral neurostring: high-density soft bioelectronic fibers for multimodal sensing and stimulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592902/ https://www.ncbi.nlm.nih.gov/pubmed/37873341 http://dx.doi.org/10.1101/2023.10.02.560482 |
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