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Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli
The dimeric two-pore OSCA/TMEM63 family has recently been identified as mechanically activated ion channels. Previously, based on the unique features of the structure of OSCA1.2, we postulated the potential involvement of several structural elements in sensing membrane tension(1). Interestingly, whi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592937/ https://www.ncbi.nlm.nih.gov/pubmed/37873218 http://dx.doi.org/10.1101/2023.10.03.560740 |