Transcription factor stoichiometry, motif affinity and syntax regulate single-cell chromatin dynamics during fibroblast reprogramming to pluripotency

Ectopic expression of OCT4, SOX2, KLF4 and MYC (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially during the early stages, we profiled chromatin accessibility and gene expression at single-cell resolution a...

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Detalles Bibliográficos
Autores principales: Nair, Surag, Ameen, Mohamed, Sundaram, Laksshman, Pampari, Anusri, Schreiber, Jacob, Balsubramani, Akshay, Wang, Yu Xin, Burns, David, Blau, Helen M, Karakikes, Ioannis, Wang, Kevin C, Kundaje, Anshul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592962/
https://www.ncbi.nlm.nih.gov/pubmed/37873116
http://dx.doi.org/10.1101/2023.10.04.560808

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