GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci...

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Autores principales: Dand, Nick, Stuart, Philip E, Bowes, John, Ellinghaus, David, Nititham, Joanne, Saklatvala, Jake R, Teder-Laving, Maris, Thomas, Laurent F, Traks, Tanel, Uebe, Steffen, Assmann, Gunter, Baudry, David, Behrens, Frank, Billi, Allison C, Brown, Matthew A, Burkhardt, Harald, Capon, Francesca, Chung, Raymond, Curtis, Charles J, Duckworth, Michael, Ellinghaus, Eva, FitzGerald, Oliver, Gerdes, Sascha, Griffiths, Christopher E M, Gulliver, Susanne, Helliwell, Philip, Ho, Pauline, Hoffmann, Per, Holmen, Oddgeir L, Huang, Zhi-ming, Hveem, Kristian, Jadon, Deepak, Köhm, Michaela, Kraus, Cornelia, Lamacchia, Céline, Lee, Sang Hyuck, Ma, Feiyang, Mahil, Satveer K, McHugh, Neil, McManus, Ross, Modalsli, Ellen H, Nissen, Michael J, Nöthen, Markus, Oji, Vinzenz, Oksenberg, Jorge R, Patrick, Matthew T, Perez-White, Bethany E, Ramming, Andreas, Rech, Jürgen, Rosen, Cheryl, Sarkar, Mrinal K, Schett, Georg, Schmidt, Börge, Tejasvi, Trilokraj, Traupe, Heiko, Voorhees, John J, Wacker, Eike Matthias, Warren, Richard B, Wasikowski, Rachael, Weidinger, Stephan, Wen, Xiaoquan, Zhang, Zhaolin, Barton, Anne, Chandran, Vinod, Esko, Tõnu, Foerster, John, Franke, Andre, Gladman, Dafna D, Gudjonsson, Johann E, Gulliver, Wayne, Hüffmeier, Ulrike, Kingo, Külli, Kõks, Sulev, Liao, Wilson, Løset, Mari, Mägi, Reedik, Nair, Rajan P, Rahman, Proton, Reis, André, Smith, Catherine H, Di Meglio, Paola, Barker, Jonathan N, Tsoi, Lam C, Simpson, Michael A, Elder, James T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593001/
https://www.ncbi.nlm.nih.gov/pubmed/37873414
http://dx.doi.org/10.1101/2023.10.04.23296543

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