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Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database
OBJECTIVES: Leptospira, the spirochaete causing leptospirosis, can be classified into >250 antigenically distinct serovars. Although knowledge of the animal host species and geographic distribution of Leptospira serovars is critical to understand the human and animal epidemiology of leptospirosis...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593013/ https://www.ncbi.nlm.nih.gov/pubmed/37873107 http://dx.doi.org/10.1101/2023.10.03.23296503 |
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author | Hagedoorn, Nienke N. Maze, Michael J. Carugati, Manuela Cash-Goldwasser, Shama Allan, Kathryn J. Chen, Kevin Cossic, Brieuc Demeter, Elena Gallagher, Sarah German, Richard Galloway, Renee L. Habuš, Josipa Rubach, Matthew P. Shiokawa, Kanae Sulikhan, Nadezhda Crump, John A. |
author_facet | Hagedoorn, Nienke N. Maze, Michael J. Carugati, Manuela Cash-Goldwasser, Shama Allan, Kathryn J. Chen, Kevin Cossic, Brieuc Demeter, Elena Gallagher, Sarah German, Richard Galloway, Renee L. Habuš, Josipa Rubach, Matthew P. Shiokawa, Kanae Sulikhan, Nadezhda Crump, John A. |
author_sort | Hagedoorn, Nienke N. |
collection | PubMed |
description | OBJECTIVES: Leptospira, the spirochaete causing leptospirosis, can be classified into >250 antigenically distinct serovars. Although knowledge of the animal host species and geographic distribution of Leptospira serovars is critical to understand the human and animal epidemiology of leptospirosis, currently data are fragmented. We aimed to systematically review the literature on animal host species and geographic distribution of Leptospira serovars to examine associations between serovars with animal host species and regions, and to identify geographic regions in need of study. METHODS: Nine library databases were searched from inception through 9 March 2023 using keywords including Leptospira, animal, and a list of serovars. We sought reports of detection of Leptospira, from any animal, characterized by cross agglutinin absorption test, monoclonal antibody typing, serum factor analysis, or pulsed-field gel electrophoresis to identify the serovar. RESULTS: We included 409 reports, published from 1927 through 2022, yielding data on 154 Leptospira serovars. The reports included data from 66 (26.5%) of 249 countries. Detections were from 144 animal host species including 135 (93.8%) from the class Mammalia, 5 (3.5%) from Amphibia, 3 (2.1%) from Reptilia, and 1 (0.7%) from Arachnida. Across the animal host species, Leptospira serovars that were detected in the largest number of animal species included Grippotyphosa (n=39), Icterohaemorrhagiae (n=29), Pomona (n=28), Australis (n=25), and Ballum (n=25). Of serovars, 76 were detected in a single animal host species. We created an online database to identify animal host species for each serovar by country. CONCLUSIONS: We found that many countries have few or no Leptospira serovars detected from animal host species and that many serovars were detected from a single animal species. Our study highlights the importance of efforts to identify animal host species of leptospirosis, especially in places with a high incidence of human leptospirosis. We provide an updated resource for leptospirosis researchers. |
format | Online Article Text |
id | pubmed-10593013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-105930132023-10-24 Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database Hagedoorn, Nienke N. Maze, Michael J. Carugati, Manuela Cash-Goldwasser, Shama Allan, Kathryn J. Chen, Kevin Cossic, Brieuc Demeter, Elena Gallagher, Sarah German, Richard Galloway, Renee L. Habuš, Josipa Rubach, Matthew P. Shiokawa, Kanae Sulikhan, Nadezhda Crump, John A. medRxiv Article OBJECTIVES: Leptospira, the spirochaete causing leptospirosis, can be classified into >250 antigenically distinct serovars. Although knowledge of the animal host species and geographic distribution of Leptospira serovars is critical to understand the human and animal epidemiology of leptospirosis, currently data are fragmented. We aimed to systematically review the literature on animal host species and geographic distribution of Leptospira serovars to examine associations between serovars with animal host species and regions, and to identify geographic regions in need of study. METHODS: Nine library databases were searched from inception through 9 March 2023 using keywords including Leptospira, animal, and a list of serovars. We sought reports of detection of Leptospira, from any animal, characterized by cross agglutinin absorption test, monoclonal antibody typing, serum factor analysis, or pulsed-field gel electrophoresis to identify the serovar. RESULTS: We included 409 reports, published from 1927 through 2022, yielding data on 154 Leptospira serovars. The reports included data from 66 (26.5%) of 249 countries. Detections were from 144 animal host species including 135 (93.8%) from the class Mammalia, 5 (3.5%) from Amphibia, 3 (2.1%) from Reptilia, and 1 (0.7%) from Arachnida. Across the animal host species, Leptospira serovars that were detected in the largest number of animal species included Grippotyphosa (n=39), Icterohaemorrhagiae (n=29), Pomona (n=28), Australis (n=25), and Ballum (n=25). Of serovars, 76 were detected in a single animal host species. We created an online database to identify animal host species for each serovar by country. CONCLUSIONS: We found that many countries have few or no Leptospira serovars detected from animal host species and that many serovars were detected from a single animal species. Our study highlights the importance of efforts to identify animal host species of leptospirosis, especially in places with a high incidence of human leptospirosis. We provide an updated resource for leptospirosis researchers. Cold Spring Harbor Laboratory 2023-10-03 /pmc/articles/PMC10593013/ /pubmed/37873107 http://dx.doi.org/10.1101/2023.10.03.23296503 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Hagedoorn, Nienke N. Maze, Michael J. Carugati, Manuela Cash-Goldwasser, Shama Allan, Kathryn J. Chen, Kevin Cossic, Brieuc Demeter, Elena Gallagher, Sarah German, Richard Galloway, Renee L. Habuš, Josipa Rubach, Matthew P. Shiokawa, Kanae Sulikhan, Nadezhda Crump, John A. Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database |
title | Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database |
title_full | Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database |
title_fullStr | Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database |
title_full_unstemmed | Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database |
title_short | Global distribution of Leptospira serovar isolations and detections from animal host species: a systematic review and online database |
title_sort | global distribution of leptospira serovar isolations and detections from animal host species: a systematic review and online database |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593013/ https://www.ncbi.nlm.nih.gov/pubmed/37873107 http://dx.doi.org/10.1101/2023.10.03.23296503 |
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