The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development

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Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility profiling of neurons and non-neurons from two neocortical brain...

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Detalles Bibliográficos
Autores principales: Girdhar, Kiran, Bendl, Jaroslav, Baumgartner, Andrew, Therrien, Karen, Venkatesh, Sanan, Mathur, Deepika, Dong, Pengfei, Rahman, Samir, Kleopoulos, Steven P., Misir, Ruth, Reach, Sarah M., Auluck, Pavan K., Marenco, Stefano, Lewis, David A., Haroutunian, Vahram, Funk, Cory, Voloudakis, Georgios, Hoffman, Gabriel E., Fullard, John F., Roussos, Panos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593028/
https://www.ncbi.nlm.nih.gov/pubmed/37873320
http://dx.doi.org/10.1101/2023.10.02.23296067

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