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Maternal malnutrition during pregnancy among women with sickle cell disease

OBJECTIVE: The objective of this study was to compare the nutritional status and dietary intake of pregnant women with sickle cell disease (SS hemoglobinopathy and SC hemoglobinopathy) to healthy controls and report the maternal and perinatal outcomes. METHODS: This is a prospective, longitudinal co...

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Autores principales: Paiva, Leticia Vieira, Igai, Ana Maria Kondo, Nomura, Roseli Mieko Yamamoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Médica Brasileira 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593154/
https://www.ncbi.nlm.nih.gov/pubmed/37878827
http://dx.doi.org/10.1590/1806-9282.20230967
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author Paiva, Leticia Vieira
Igai, Ana Maria Kondo
Nomura, Roseli Mieko Yamamoto
author_facet Paiva, Leticia Vieira
Igai, Ana Maria Kondo
Nomura, Roseli Mieko Yamamoto
author_sort Paiva, Leticia Vieira
collection PubMed
description OBJECTIVE: The objective of this study was to compare the nutritional status and dietary intake of pregnant women with sickle cell disease (SS hemoglobinopathy and SC hemoglobinopathy) to healthy controls and report the maternal and perinatal outcomes. METHODS: This is a prospective, longitudinal cohort study. Pregnant women with a diagnosis of sickle cell disease and control group were recruited in an outpatient clinic of a tertiary care hospital in São Paulo, Brazil. Maternal anthropometric data and dietary intake data were collected at the second and third trimesters. RESULTS: A total of 49 pregnancies complicated by sickle cell disease were included. Prepregnancy body mass index was significantly lower in the SS hemoglobinopathy group (n=26, median 20.3 kg/m(2)) than the SC hemoglobinopathy group (n=23, 22.7 kg/m(2)) or control group (n=33, 23.2 kg/m(2), p<0.05). The prepregnancy nutritional status revealed significantly more women classified as underweight in the SS hemoglobinopathy group (15.4%) than in the SC hemoglobinopathy group (4.4%) and control group (1.6%, p=0.009). In the second trimester, maternal protein intake was significantly lower in SS hemoglobinopathy (73.2 g/day) and SC hemoglobinopathy (68.8 g/day) than in the control group (95.7 g/day, p=0.004). In the third trimester, only SS hemoglobinopathy mothers showed dietary intake of protein significantly lower than that of the controls (67.5 g/day vs. 92.8 g/day, p=0.02). Vitamin A and E consumption was also reduced in the third trimester in the SS hemoglobinopathy group (p<0.05). CONCLUSION: The nutritional status of pregnant women with SS hemoglobinopathy is characterized by a state of undernutrition. The lower protein intake in the second and third trimesters of pregnant women with SS hemoglobinopathy may contribute to this condition. Undernourishment is a serious complication of sickle cell disease, primarily during pregnancy, and it should be addressed during the prenatal period.
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spelling pubmed-105931542023-10-24 Maternal malnutrition during pregnancy among women with sickle cell disease Paiva, Leticia Vieira Igai, Ana Maria Kondo Nomura, Roseli Mieko Yamamoto Rev Assoc Med Bras (1992) Original Article OBJECTIVE: The objective of this study was to compare the nutritional status and dietary intake of pregnant women with sickle cell disease (SS hemoglobinopathy and SC hemoglobinopathy) to healthy controls and report the maternal and perinatal outcomes. METHODS: This is a prospective, longitudinal cohort study. Pregnant women with a diagnosis of sickle cell disease and control group were recruited in an outpatient clinic of a tertiary care hospital in São Paulo, Brazil. Maternal anthropometric data and dietary intake data were collected at the second and third trimesters. RESULTS: A total of 49 pregnancies complicated by sickle cell disease were included. Prepregnancy body mass index was significantly lower in the SS hemoglobinopathy group (n=26, median 20.3 kg/m(2)) than the SC hemoglobinopathy group (n=23, 22.7 kg/m(2)) or control group (n=33, 23.2 kg/m(2), p<0.05). The prepregnancy nutritional status revealed significantly more women classified as underweight in the SS hemoglobinopathy group (15.4%) than in the SC hemoglobinopathy group (4.4%) and control group (1.6%, p=0.009). In the second trimester, maternal protein intake was significantly lower in SS hemoglobinopathy (73.2 g/day) and SC hemoglobinopathy (68.8 g/day) than in the control group (95.7 g/day, p=0.004). In the third trimester, only SS hemoglobinopathy mothers showed dietary intake of protein significantly lower than that of the controls (67.5 g/day vs. 92.8 g/day, p=0.02). Vitamin A and E consumption was also reduced in the third trimester in the SS hemoglobinopathy group (p<0.05). CONCLUSION: The nutritional status of pregnant women with SS hemoglobinopathy is characterized by a state of undernutrition. The lower protein intake in the second and third trimesters of pregnant women with SS hemoglobinopathy may contribute to this condition. Undernourishment is a serious complication of sickle cell disease, primarily during pregnancy, and it should be addressed during the prenatal period. Associação Médica Brasileira 2023-10-23 /pmc/articles/PMC10593154/ /pubmed/37878827 http://dx.doi.org/10.1590/1806-9282.20230967 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Paiva, Leticia Vieira
Igai, Ana Maria Kondo
Nomura, Roseli Mieko Yamamoto
Maternal malnutrition during pregnancy among women with sickle cell disease
title Maternal malnutrition during pregnancy among women with sickle cell disease
title_full Maternal malnutrition during pregnancy among women with sickle cell disease
title_fullStr Maternal malnutrition during pregnancy among women with sickle cell disease
title_full_unstemmed Maternal malnutrition during pregnancy among women with sickle cell disease
title_short Maternal malnutrition during pregnancy among women with sickle cell disease
title_sort maternal malnutrition during pregnancy among women with sickle cell disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593154/
https://www.ncbi.nlm.nih.gov/pubmed/37878827
http://dx.doi.org/10.1590/1806-9282.20230967
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