A Rare Case of Refractory Catastrophic Antiphospholipid Syndrome Successfully Treated With Rituximab and Plasma Exchange

A small subset of patients with antiphospholipid syndrome (APS) may develop widespread thrombotic disease with organ damage, referred to as catastrophic APS (CAPS) that is associated with a high mortality. Medical therapy typically involves a combination of anticoagulation, systemic glucocorticoids,...

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Detalles Bibliográficos
Autores principales: Bangolo, Ayrton, Sagireddy, Sowmya, Mahamadeen, Sarah, Hasta, Felicia, Reddy, Sadhu A., Naz, Afshan, Ranganatha, Ravishankar, Ricketts, Cleveland, Muppalla, Padmavathi, Veliginti, Swathi, Arana, Georgemar, Sathyarajan, Dily T., Singh, Sachin, Shetty, Tanvi, Bhardwaj, Kshitij, Hashemy, Sayed, Duran, Roberto L., Kim, Sung H., Hipolito, Candice M., Yoon, Kibo, Patel, Vrusha, Alshimari, Aseel, Inban, Pugazhendi, Yasmeen, Saaniya, Weissman, Simcha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Greater Baltimore Medical Center 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593160/
https://www.ncbi.nlm.nih.gov/pubmed/37877050
http://dx.doi.org/10.55729/2000-9666.1175
Descripción
Sumario:A small subset of patients with antiphospholipid syndrome (APS) may develop widespread thrombotic disease with organ damage, referred to as catastrophic APS (CAPS) that is associated with a high mortality. Medical therapy typically involves a combination of anticoagulation, systemic glucocorticoids, plasmapheresis, and intravenous immune globulin (IVIG). There is currently no consensus for the management of refractory cases of CAPS. However, monoclonal antibodies such as rituximab and eculizumab have shown some benefits. Herein, we present a 29-year-old female with previous pulmonary embolism who presented with necrotic left toes and was eventually diagnosed with refractory CAPS, successfully treated with Plasmapheresis and Rituximab. With this case report, we hope to encourage the usage of Rituximab in the management of CAPS.

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