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Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers

With the development of immunotherapy, the process of tumor treatment is also moving forward. Polysaccharides are biological response modifiers widely found in plants, animals, fungi, and algae and are mainly composed of monosaccharides covalently linked by glycosidic bonds. For a long time, polysac...

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Autores principales: Xiong, Hongtai, Han, Xinpu, Cai, Liu, Zheng, Honggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593453/
https://www.ncbi.nlm.nih.gov/pubmed/37876967
http://dx.doi.org/10.3389/fonc.2023.1274048
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author Xiong, Hongtai
Han, Xinpu
Cai, Liu
Zheng, Honggang
author_facet Xiong, Hongtai
Han, Xinpu
Cai, Liu
Zheng, Honggang
author_sort Xiong, Hongtai
collection PubMed
description With the development of immunotherapy, the process of tumor treatment is also moving forward. Polysaccharides are biological response modifiers widely found in plants, animals, fungi, and algae and are mainly composed of monosaccharides covalently linked by glycosidic bonds. For a long time, polysaccharides have been widely used clinically to enhance the body’s immunity. However, their mechanisms of action in tumor immunotherapy have not been thoroughly explored. Dendritic cells (DCs) are a heterogeneous population of antigen presenting cells (APCs) that play a crucial role in the regulation and maintenance of the immune response. There is growing evidence that polysaccharides can enhance the essential functions of DCs to intervene the immune response. This paper describes the research progress on the anti-tumor immune effects of natural polysaccharides on DCs. These studies show that polysaccharides can act on pattern recognition receptors (PRRs) on the surface of DCs and activate phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB), Dectin-1/Syk, and other signalling pathways, thereby promoting the main functions of DCs such as maturation, metabolism, antigen uptake and presentation, and activation of T cells, and then play an anti-tumor role. In addition, the application of polysaccharides as adjuvants for DC vaccines, in combination with adoptive immunotherapy and immune checkpoint inhibitors (ICIs), as well as their co-assembly with nanoparticles (NPs) into nano drug delivery systems is also introduced. These results reveal the biological effects of polysaccharides, provide a new perspective for the anti-tumor immunopharmacological research of natural polysaccharides, and provide helpful information for guiding polysaccharides as complementary medicines in cancer immunotherapy.
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spelling pubmed-105934532023-10-24 Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers Xiong, Hongtai Han, Xinpu Cai, Liu Zheng, Honggang Front Oncol Oncology With the development of immunotherapy, the process of tumor treatment is also moving forward. Polysaccharides are biological response modifiers widely found in plants, animals, fungi, and algae and are mainly composed of monosaccharides covalently linked by glycosidic bonds. For a long time, polysaccharides have been widely used clinically to enhance the body’s immunity. However, their mechanisms of action in tumor immunotherapy have not been thoroughly explored. Dendritic cells (DCs) are a heterogeneous population of antigen presenting cells (APCs) that play a crucial role in the regulation and maintenance of the immune response. There is growing evidence that polysaccharides can enhance the essential functions of DCs to intervene the immune response. This paper describes the research progress on the anti-tumor immune effects of natural polysaccharides on DCs. These studies show that polysaccharides can act on pattern recognition receptors (PRRs) on the surface of DCs and activate phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB), Dectin-1/Syk, and other signalling pathways, thereby promoting the main functions of DCs such as maturation, metabolism, antigen uptake and presentation, and activation of T cells, and then play an anti-tumor role. In addition, the application of polysaccharides as adjuvants for DC vaccines, in combination with adoptive immunotherapy and immune checkpoint inhibitors (ICIs), as well as their co-assembly with nanoparticles (NPs) into nano drug delivery systems is also introduced. These results reveal the biological effects of polysaccharides, provide a new perspective for the anti-tumor immunopharmacological research of natural polysaccharides, and provide helpful information for guiding polysaccharides as complementary medicines in cancer immunotherapy. Frontiers Media S.A. 2023-10-09 /pmc/articles/PMC10593453/ /pubmed/37876967 http://dx.doi.org/10.3389/fonc.2023.1274048 Text en Copyright © 2023 Xiong, Han, Cai and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xiong, Hongtai
Han, Xinpu
Cai, Liu
Zheng, Honggang
Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
title Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
title_full Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
title_fullStr Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
title_full_unstemmed Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
title_short Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
title_sort natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593453/
https://www.ncbi.nlm.nih.gov/pubmed/37876967
http://dx.doi.org/10.3389/fonc.2023.1274048
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