Cargando…
A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa
Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole gen...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593746/ https://www.ncbi.nlm.nih.gov/pubmed/37872141 http://dx.doi.org/10.1038/s41467-023-41152-6 |
_version_ | 1785124496969039872 |
---|---|
author | Van Puyvelde, Sandra de Block, Tessa Sridhar, Sushmita Bawn, Matt Kingsley, Robert A. Ingelbeen, Brecht Beale, Mathew A. Barbé, Barbara Jeon, Hyon Jin Mbuyi-Kalonji, Lisette Phoba, Marie-France Falay, Dadi Martiny, Delphine Vandenberg, Olivier Affolabi, Dissou Rutanga, Jean Pierre Ceyssens, Pieter-Jan Mattheus, Wesley Cuypers, Wim L. van der Sande, Marianne A. B. Park, Se Eun Kariuki, Simon Otieno, Kephas Lusingu, John P. A. Mbwana, Joyce R. Adjei, Samuel Sarfo, Anima Agyei, Seth O. Asante, Kwaku P. Otieno, Walter Otieno, Lucas Tahita, Marc C. Lompo, Palpouguini Hoffman, Irving F. Mvalo, Tisungane Msefula, Chisomo Hassan-Hanga, Fatimah Obaro, Stephen Mackenzie, Grant Deborggraeve, Stijn Feasey, Nicholas Marks, Florian MacLennan, Calman A. Thomson, Nicholas R. Jacobs, Jan Dougan, Gordon Kariuki, Samuel Lunguya, Octavie |
author_facet | Van Puyvelde, Sandra de Block, Tessa Sridhar, Sushmita Bawn, Matt Kingsley, Robert A. Ingelbeen, Brecht Beale, Mathew A. Barbé, Barbara Jeon, Hyon Jin Mbuyi-Kalonji, Lisette Phoba, Marie-France Falay, Dadi Martiny, Delphine Vandenberg, Olivier Affolabi, Dissou Rutanga, Jean Pierre Ceyssens, Pieter-Jan Mattheus, Wesley Cuypers, Wim L. van der Sande, Marianne A. B. Park, Se Eun Kariuki, Simon Otieno, Kephas Lusingu, John P. A. Mbwana, Joyce R. Adjei, Samuel Sarfo, Anima Agyei, Seth O. Asante, Kwaku P. Otieno, Walter Otieno, Lucas Tahita, Marc C. Lompo, Palpouguini Hoffman, Irving F. Mvalo, Tisungane Msefula, Chisomo Hassan-Hanga, Fatimah Obaro, Stephen Mackenzie, Grant Deborggraeve, Stijn Feasey, Nicholas Marks, Florian MacLennan, Calman A. Thomson, Nicholas R. Jacobs, Jan Dougan, Gordon Kariuki, Samuel Lunguya, Octavie |
author_sort | Van Puyvelde, Sandra |
collection | PubMed |
description | Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S. Typhimurium isolates originating from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S. Typhimurium across many of Africa’s most impacted countries. At least six invasive S. Typhimurium clades have already emerged, with ST313 lineage 2 or ST313-L2 driving the current pandemic. ST313-L2 likely emerged in the Democratic Republic of Congo around 1980 and further spread in the mid 1990s. We observed plasmid-borne as well as chromosomally encoded fluoroquinolone resistance underlying emergences of extensive-drug and pan-drug resistance. Our work provides an overview of the evolution of invasive S. Typhimurium disease, and can be exploited to target control measures. |
format | Online Article Text |
id | pubmed-10593746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105937462023-10-25 A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa Van Puyvelde, Sandra de Block, Tessa Sridhar, Sushmita Bawn, Matt Kingsley, Robert A. Ingelbeen, Brecht Beale, Mathew A. Barbé, Barbara Jeon, Hyon Jin Mbuyi-Kalonji, Lisette Phoba, Marie-France Falay, Dadi Martiny, Delphine Vandenberg, Olivier Affolabi, Dissou Rutanga, Jean Pierre Ceyssens, Pieter-Jan Mattheus, Wesley Cuypers, Wim L. van der Sande, Marianne A. B. Park, Se Eun Kariuki, Simon Otieno, Kephas Lusingu, John P. A. Mbwana, Joyce R. Adjei, Samuel Sarfo, Anima Agyei, Seth O. Asante, Kwaku P. Otieno, Walter Otieno, Lucas Tahita, Marc C. Lompo, Palpouguini Hoffman, Irving F. Mvalo, Tisungane Msefula, Chisomo Hassan-Hanga, Fatimah Obaro, Stephen Mackenzie, Grant Deborggraeve, Stijn Feasey, Nicholas Marks, Florian MacLennan, Calman A. Thomson, Nicholas R. Jacobs, Jan Dougan, Gordon Kariuki, Samuel Lunguya, Octavie Nat Commun Article Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S. Typhimurium isolates originating from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S. Typhimurium across many of Africa’s most impacted countries. At least six invasive S. Typhimurium clades have already emerged, with ST313 lineage 2 or ST313-L2 driving the current pandemic. ST313-L2 likely emerged in the Democratic Republic of Congo around 1980 and further spread in the mid 1990s. We observed plasmid-borne as well as chromosomally encoded fluoroquinolone resistance underlying emergences of extensive-drug and pan-drug resistance. Our work provides an overview of the evolution of invasive S. Typhimurium disease, and can be exploited to target control measures. Nature Publishing Group UK 2023-10-23 /pmc/articles/PMC10593746/ /pubmed/37872141 http://dx.doi.org/10.1038/s41467-023-41152-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Van Puyvelde, Sandra de Block, Tessa Sridhar, Sushmita Bawn, Matt Kingsley, Robert A. Ingelbeen, Brecht Beale, Mathew A. Barbé, Barbara Jeon, Hyon Jin Mbuyi-Kalonji, Lisette Phoba, Marie-France Falay, Dadi Martiny, Delphine Vandenberg, Olivier Affolabi, Dissou Rutanga, Jean Pierre Ceyssens, Pieter-Jan Mattheus, Wesley Cuypers, Wim L. van der Sande, Marianne A. B. Park, Se Eun Kariuki, Simon Otieno, Kephas Lusingu, John P. A. Mbwana, Joyce R. Adjei, Samuel Sarfo, Anima Agyei, Seth O. Asante, Kwaku P. Otieno, Walter Otieno, Lucas Tahita, Marc C. Lompo, Palpouguini Hoffman, Irving F. Mvalo, Tisungane Msefula, Chisomo Hassan-Hanga, Fatimah Obaro, Stephen Mackenzie, Grant Deborggraeve, Stijn Feasey, Nicholas Marks, Florian MacLennan, Calman A. Thomson, Nicholas R. Jacobs, Jan Dougan, Gordon Kariuki, Samuel Lunguya, Octavie A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
title | A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
title_full | A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
title_fullStr | A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
title_full_unstemmed | A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
title_short | A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa |
title_sort | genomic appraisal of invasive salmonella typhimurium and associated antibiotic resistance in sub-saharan africa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593746/ https://www.ncbi.nlm.nih.gov/pubmed/37872141 http://dx.doi.org/10.1038/s41467-023-41152-6 |
work_keys_str_mv | AT vanpuyveldesandra agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT deblocktessa agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT sridharsushmita agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT bawnmatt agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT kingsleyroberta agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT ingelbeenbrecht agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT bealemathewa agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT barbebarbara agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT jeonhyonjin agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mbuyikalonjilisette agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT phobamariefrance agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT falaydadi agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT martinydelphine agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT vandenbergolivier agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT affolabidissou agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT rutangajeanpierre agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT ceyssenspieterjan agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mattheuswesley agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT cuyperswiml agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT vandersandemarianneab agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT parkseeun agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT kariukisimon agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT otienokephas agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT lusingujohnpa agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mbwanajoycer agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT adjeisamuel agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT sarfoanima agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT agyeisetho agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT asantekwakup agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT otienowalter agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT otienolucas agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT tahitamarcc agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT lompopalpouguini agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT hoffmanirvingf agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mvalotisungane agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT msefulachisomo agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT hassanhangafatimah agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT obarostephen agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mackenziegrant agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT deborggraevestijn agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT feaseynicholas agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT marksflorian agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT maclennancalmana agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT thomsonnicholasr agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT jacobsjan agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT dougangordon agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT kariukisamuel agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT lunguyaoctavie agenomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT vanpuyveldesandra genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT deblocktessa genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT sridharsushmita genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT bawnmatt genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT kingsleyroberta genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT ingelbeenbrecht genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT bealemathewa genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT barbebarbara genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT jeonhyonjin genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mbuyikalonjilisette genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT phobamariefrance genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT falaydadi genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT martinydelphine genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT vandenbergolivier genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT affolabidissou genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT rutangajeanpierre genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT ceyssenspieterjan genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mattheuswesley genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT cuyperswiml genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT vandersandemarianneab genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT parkseeun genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT kariukisimon genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT otienokephas genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT lusingujohnpa genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mbwanajoycer genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT adjeisamuel genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT sarfoanima genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT agyeisetho genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT asantekwakup genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT otienowalter genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT otienolucas genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT tahitamarcc genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT lompopalpouguini genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT hoffmanirvingf genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mvalotisungane genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT msefulachisomo genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT hassanhangafatimah genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT obarostephen genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT mackenziegrant genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT deborggraevestijn genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT feaseynicholas genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT marksflorian genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT maclennancalmana genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT thomsonnicholasr genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT jacobsjan genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT dougangordon genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT kariukisamuel genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica AT lunguyaoctavie genomicappraisalofinvasivesalmonellatyphimuriumandassociatedantibioticresistanceinsubsaharanafrica |