Interferon-γ couples CD8(+) T cell avidity and differentiation during infection

Effective responses to intracellular pathogens are characterized by T cell clones with a broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell clones are selected throughout the response to retain a breadth of avidities remains unclear. Here, we demonstrate tha...

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Detalles Bibliográficos
Autores principales: Uhl, Lion F. K., Cai, Han, Oram, Sophia L., Mahale, Jagdish N., MacLean, Andrew J., Mazet, Julie M., Piccirilli, Theo, He, Alexander J., Lau, Doreen, Elliott, Tim, Gerard, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593754/
https://www.ncbi.nlm.nih.gov/pubmed/37872155
http://dx.doi.org/10.1038/s41467-023-42455-4

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