Domain adapted brain network fusion captures variance related to pubertal brain development and mental health

Puberty demarks a period of profound brain dynamics that orchestrates changes to a multitude of neuroimaging-derived phenotypes. This complexity poses a dimensionality problem when attempting to chart an individual’s brain development over time. Here, we illustrate that shifts in subject similarity...

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Autores principales: Kraft, Dominik, Alnæs, Dag, Kaufmann, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593774/
https://www.ncbi.nlm.nih.gov/pubmed/37872174
http://dx.doi.org/10.1038/s41467-023-41839-w
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author Kraft, Dominik
Alnæs, Dag
Kaufmann, Tobias
author_facet Kraft, Dominik
Alnæs, Dag
Kaufmann, Tobias
author_sort Kraft, Dominik
collection PubMed
description Puberty demarks a period of profound brain dynamics that orchestrates changes to a multitude of neuroimaging-derived phenotypes. This complexity poses a dimensionality problem when attempting to chart an individual’s brain development over time. Here, we illustrate that shifts in subject similarity of brain imaging data relate to pubertal maturation in the longitudinal ABCD study. Given that puberty depicts a critical window for emerging mental health issues, we additionally show that our model is capable of capturing variance in the adolescent brain related to psychopathology in a population-based and a clinical cohort. These results suggest that low-dimensional reference spaces based on subject similarities render useful to chart variance in brain development in youths.
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spelling pubmed-105937742023-10-25 Domain adapted brain network fusion captures variance related to pubertal brain development and mental health Kraft, Dominik Alnæs, Dag Kaufmann, Tobias Nat Commun Article Puberty demarks a period of profound brain dynamics that orchestrates changes to a multitude of neuroimaging-derived phenotypes. This complexity poses a dimensionality problem when attempting to chart an individual’s brain development over time. Here, we illustrate that shifts in subject similarity of brain imaging data relate to pubertal maturation in the longitudinal ABCD study. Given that puberty depicts a critical window for emerging mental health issues, we additionally show that our model is capable of capturing variance in the adolescent brain related to psychopathology in a population-based and a clinical cohort. These results suggest that low-dimensional reference spaces based on subject similarities render useful to chart variance in brain development in youths. Nature Publishing Group UK 2023-10-23 /pmc/articles/PMC10593774/ /pubmed/37872174 http://dx.doi.org/10.1038/s41467-023-41839-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kraft, Dominik
Alnæs, Dag
Kaufmann, Tobias
Domain adapted brain network fusion captures variance related to pubertal brain development and mental health
title Domain adapted brain network fusion captures variance related to pubertal brain development and mental health
title_full Domain adapted brain network fusion captures variance related to pubertal brain development and mental health
title_fullStr Domain adapted brain network fusion captures variance related to pubertal brain development and mental health
title_full_unstemmed Domain adapted brain network fusion captures variance related to pubertal brain development and mental health
title_short Domain adapted brain network fusion captures variance related to pubertal brain development and mental health
title_sort domain adapted brain network fusion captures variance related to pubertal brain development and mental health
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593774/
https://www.ncbi.nlm.nih.gov/pubmed/37872174
http://dx.doi.org/10.1038/s41467-023-41839-w
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