The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping. Disruption of OPA1 causes mitochondrial dysfunction. However, the role of OPA1 in liver...

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Detalles Bibliográficos
Autores principales: Lee, Hakjoo, Lee, Tae Jin, Galloway, Chad A., Zhi, Wenbo, Xiao, Wei, de Mesy Bentley, Karen L., Sharma, Ashok, Teng, Yong, Sesaki, Hiromi, Yoon, Yisang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593833/
https://www.ncbi.nlm.nih.gov/pubmed/37872238
http://dx.doi.org/10.1038/s41467-023-42564-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593833/
https://www.ncbi.nlm.nih.gov/pubmed/37872238
http://dx.doi.org/10.1038/s41467-023-42564-0

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