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Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir

The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4) from interacting with the envelope glycoprotein (Env) and blocks its conformational changes. To do this, temsavir relies on the presence of a residue with small side chain at position 375 in Env and is...

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Detalles Bibliográficos
Autores principales:	Prévost, Jérémie, Chen, Yaozong, Zhou, Fei, Tolbert, William D., Gasser, Romain, Medjahed, Halima, Nayrac, Manon, Nguyen, Dung N., Gottumukkala, Suneetha, Hessell, Ann J., Rao, Venigalla B., Pozharski, Edwin, Huang, Rick K., Matthies, Doreen, Finzi, Andrés, Pazgier, Marzena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593844/ https://www.ncbi.nlm.nih.gov/pubmed/37872202 http://dx.doi.org/10.1038/s41467-023-42500-2

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