Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma

Increasing evidence has demonstrated that drug resistance can be acquired in cancer cells by kinase rewiring, which is an obstacle for efficient cancer therapy. However, it is technically challenging to measure the expression of protein kinases on large scale due to their dynamic range in human prot...

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Detalles Bibliográficos
Autores principales: Leung, Carmen Oi Ning, Yang, Yang, Leung, Rainbow Wing Hei, So, Karl Kam Hei, Guo, Hai Jun, Lei, Martina Mang Leng, Muliawan, Gregory Kenneth, Gao, Yuan, Yu, Qian Qian, Yun, Jing Ping, Ma, Stephanie, Zhao, Qian, Lee, Terence Kin Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593849/
https://www.ncbi.nlm.nih.gov/pubmed/37872167
http://dx.doi.org/10.1038/s41467-023-42360-w

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