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Gpr88 Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine

BACKGROUND: Disrupted motivational control is a common—but poorly treated—feature of psychiatric disorders, arising via aberrant mesolimbic dopaminergic signaling. GPR88 is an orphan G protein–coupled receptor that is highly expressed in the striatum and therefore well placed to modulate disrupted s...

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Detalles Bibliográficos
Autores principales: Spark, Daisy L., Vermeulen, Michela H., de la Fuente Gonzalez, Rocío A., Hatzipantelis, Cassandra J., Rueda, Patricia, Sepehrizadeh, Tara, De Veer, Michael, Mannoury la Cour, Clotilde, Fornito, Alex, Langiu, Monica, Stewart, Gregory D., Nithianantharajah, Jess, Langmead, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593871/
https://www.ncbi.nlm.nih.gov/pubmed/37881541
http://dx.doi.org/10.1016/j.bpsgos.2022.10.008