DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts

Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of cancer patients. Recent evidence suggests that epigenetic therapies synergize with immunotherapies, mediated by the de-repression of endogenous retroviral element (ERV)-encoded promoters, and the initiation of...

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Detalles Bibliográficos
Autores principales: Goyal, Ashish, Bauer, Jens, Hey, Joschka, Papageorgiou, Dimitris N., Stepanova, Ekaterina, Daskalakis, Michael, Scheid, Jonas, Dubbelaar, Marissa, Klimovich, Boris, Schwarz, Dominic, Märklin, Melanie, Roerden, Malte, Lin, Yu-Yu, Ma, Tobias, Mücke, Oliver, Rammensee, Hans-Georg, Lübbert, Michael, Loayza-Puch, Fabricio, Krijgsveld, Jeroen, Walz, Juliane S., Plass, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593957/
https://www.ncbi.nlm.nih.gov/pubmed/37872136
http://dx.doi.org/10.1038/s41467-023-42417-w

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